Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons.

@article{Chen2001RoleOT,
  title={Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons.},
  author={Wei Qun Chen and Hong Jin and Maidung Nguyen and Jenny Carr and Yoon Jin Lee and Cynthia C-H Hsu and Morris D Faiman and John V. Schloss and J. Y. Wu},
  journal={Journal of neuroscience research},
  year={2001},
  volume={66 4},
  pages={612-9}
}
Glutamate-induced excitotoxicity has been implicated as an important mechanism underlying a variety of brain injuries and neurodegenerative diseases. Previously we have shown that taurine has protective effects against glutamate-induced neuronal injury in cultured neurons. Here we propose that the primary underlying mechanism of the neuroprotective function of taurine is due to its action in preventing or reducing glutamate-induced elevation of intracellular free calcium, [Ca(2+)](i). This… CONTINUE READING

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