Role of tRNA modifications in human diseases.

  title={Role of tRNA modifications in human diseases.},
  author={Adrian G Torres and Eduard Batlle and Lluis Ribas de Pouplana},
  journal={Trends in molecular medicine},
  volume={20 6},
Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates that tRNA modifications and the enzymes catalyzing such modifications may play important roles in complex human pathologies. Here, we have compiled current knowledge that directly link tRNA modifications to human diseases such as cancer, type 2 diabetes (T2D), neurological disorders, and mitochondrial-linked… CONTINUE READING