Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

@article{Brassai2015RoleOS,
  title={Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity},
  author={Attila Brassai and R. -G. Suvanjeiev and Erika B{\'a}n and Marcell Lakatos},
  journal={Brain Research Bulletin},
  year={2015},
  volume={112},
  pages={1-6}
}
View on Elsevier
doi.org
83 Citations
Highly Influential Citations
2
Background Citations
33
Methods Citations
1

Figures from this paper

83 Citations

Citation Type

Citation Type

Astrocyte control of neurotransmitter signalling
Astrocytes interact with, and regulate the activity of, neurons by various mechanisms. They can release molecules known as gliotransmitters which act on neuronal receptors, or they can regulate the…
Atypical Expression and Activation of GluN2A- and GluN2B-Containing NMDA Receptors at Ganglion Cells during Retinal Degeneration
Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability
  • B. Pál
  • Biology
    Cellular and Molecular Life Sciences
  • 2018
TLDR
The extrasynaptic glutamatergic system is affected in several brain pathologies related to excitotoxicity, neurodegeneration or neuroinflammation, and is involved in several physiological phenomena of the central nervous system.
Glutamate transporters: Gene expression regulation and signaling properties
Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects
TLDR
The findings suggest that the DAPK1 interaction with the NMDAR GluN2B subunit acts as a critical component in the pathophysiology of depression and is a potential target for new antidepressant treatments.
Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia.
N-Methyl-D-Aspartate Receptor Signaling-Protein Kinases Crosstalk in Cerebral Ischemia.
TLDR
Considering the dual roles of NMDA receptors in both promoting neuronal survival and mediating neuronal damage, selective augmentation of NR2A-containing NMDA receptor activation in the presence ofNR2B antagonist may constitute a promising therapy for stroke.
G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia
TLDR
GPR37L1 protects neurons during ischemia, presumably by modulating extracellular glutamate concentration and NMDAR activation, and inhibited astrocytes and oligodendrocyte glutamate transporters and reduced neuronal NMDA receptor activity during prolonged activation of the receptors.
Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine
TLDR
Density of mGluR1 is rapidly upregulated by increases in basal Glu concentration, suggesting that mGLUR1 might to be a potential biomarker of abnormal conditions in the brain.
Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models
...
...

References

SHOWING 1-10 OF 111 REFERENCES
Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron…
NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo
TLDR
The present work provides a molecular basis for the dual roles of NMDA receptors in promoting neuronal survival and mediating neuronal damage and suggests that selective enhancement of NR2A-containing NMDA receptor activation with glycine may constitute a promising therapy for stroke.
Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
  • S. Rothman
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1984
TLDR
Results provide convincing evidence that the synaptic release of excitatory transmitter mediates the death of anoxic neurons, and suggests new strategies that may be effective in preventing the devastating insults produced by cerebral hypoxia and ischemia in man.
Oxidative stress, glutamate, and neurodegenerative disorders.
TLDR
Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.
Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-d-aspartate receptors
The role of non-synaptic extracellular glutamate
The Role of Extracellular Adenosine in Chemical Neurotransmission in the Hippocampus and Basal Ganglia: Pharmacological and Clinical Aspects
TLDR
These actions underlie modulation of neuronal excitability, synaptic plasticity and coordination of neural networks and provide intriguing target sites for pharmacological intervention in ischemia and Parkinson’s disease.
...
...