Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane-anesthetized rats.

  title={Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane-anesthetized rats.},
  author={Patrick J Lacolley and Stephen J. Lewis and Michael J. Brody},
  volume={17 6 Pt 2},
The aim of the present study was to examine the involvement of the sympathetic nervous system in the generation or release of vascular nitric oxide. In urethane-anesthetized rats, the administration of the novel nitric oxide synthesis inhibitor L-N-nitro arginine (LNA) (0.02 mmol/kg i.v.) increased mean arterial pressure and renal, mesenteric, and hindquarter vascular resistances. The intravenous administration of L-arginine (60 mg/kg plus 12 mg/kg/min i.v.) produced small reductions in… CONTINUE READING


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