Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates.

@article{Ghio1992RoleOS,
  title={Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates.},
  author={Andrew J Ghio and Thomas P Kennedy and A. Richard Whorton and Alvin L. Crumbliss and Gary E. Hatch and John R. Hoidal},
  journal={The American journal of physiology},
  year={1992},
  volume={263 5 Pt 1},
  pages={L511-8}
}
Inhalation of silicates induces a variety of lung diseases in humans. The molecular mechanism(s) by which these dusts cause disease is not known. Because several naturally occurring mineral oxides have large amounts of transition metal ions on their surfaces, we tested the hypothesis that surface complexation of iron may be an important determinant of their ability to induce disease. Silica, crocidolite, kaolinite, and talc complexed considerable concentrations of Fe3+ onto their surfaces from… CONTINUE READING
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