Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons

@article{Sunico2016RoleOS,
  title={Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons},
  author={C. R. Sunico and Abdullah Sultan and Tomohiro Nakamura and Nima Dolatabadi and James Parker and B. Shan and Xuemei Han and J. Yates and E. Masliah and R. Ambasudhan and N. Nakanishi and S. Lipton},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={113},
  pages={E7564 - E7571}
}
Significance S-nitrosylation, addition of an NO group to a cysteine thiol, can regulate protein activity. Aberrant protein S-nitrosylation, however, can disrupt normal enzyme function, as is the case for S-nitrosylated peroxiredoxin (SNO-Prx), which would otherwise catabolize toxic peroxides that occur under neurodegenerative conditions such as Parkinson’s disease. Here, we describe a paradigm of N-phosphorylation–mediated denitrosylation by the enzyme sulfiredoxin that removes NO from Prx. The… Expand
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