Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds.

@article{Klaassen1985RoleOS,
  title={Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds.},
  author={Curtis D. Klaassen and William M. Bracken and Robert E Dudley and Peter L. Goering and G A Hazelton and J J Hjelle},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1985},
  volume={5 5},
  pages={806-15}
}
Endogenous sulfhydryl compounds serve a critical role in maintaining the function and viability of living systems. Glutathione (GSH) is the most abundant of these nonprotein thiols. During the past decade it has been demonstrated that sulfhydryls such as GSH also serve an important role in protecting vital nucleophilic sites in the liver from electrophilic attack by numerous classes of reactive chemicals. Organocompounds such as bromobenzene and acetaminophen which undergo microsomal metabolism… CONTINUE READING

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