Role of suilysin in pathogenesis of Streptococcus suis capsular serotype 2.

@article{Lun2003RoleOS,
  title={Role of suilysin in pathogenesis of Streptococcus suis capsular serotype 2.},
  author={Shichun Lun and Jos{\'e} Perez-Casal and Wayne Connor and Philip James Willson},
  journal={Microbial pathogenesis},
  year={2003},
  volume={34 1},
  pages={27-37}
}
Three suilysin (SLY) knockout mutant strains of Streptococcus suis serotype 2 were generated by allelic replacement from one North American and two European wild type strains. The mutants were characterized by Southern blot, Western blot and phenotyping. In vitro bactericidal testing showed that both wild type and SLY mutants were resistant to bactericidal factors in whole pig blood. To demonstrate the role of SLY during S. suis infection, four animal trials were carried out using young pigs… CONTINUE READING