Role of substrate unbinding in Michaelis-Menten enzymatic reactions.


The Michaelis-Menten equation provides a hundred-year-old prediction by which any increase in the rate of substrate unbinding will decrease the rate of enzymatic turnover. Surprisingly, this prediction was never tested experimentally nor was it scrutinized using modern theoretical tools. Here we show that unbinding may also speed up enzymatic turnover… (More)
DOI: 10.1073/pnas.1318122111


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@article{Reuveni2014RoleOS, title={Role of substrate unbinding in Michaelis-Menten enzymatic reactions.}, author={Shlomi Reuveni and Michael Urbakh and Joseph Klafter}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2014}, volume={111 12}, pages={4391-6} }