Role of substance P (SP) in development of symptoms of neurogenic inflammation in the oral mucosa of the rat.

@article{Gyrfi1993RoleOS,
  title={Role of substance P (SP) in development of symptoms of neurogenic inflammation in the oral mucosa of the rat.},
  author={Adrienne Gy{\"o}rfi and Arp{\'a}d Fazekas and F. Irmes and G{\'a}bor Jakab and T S{\"u}t{\"o} and L{\'a}sz1{\'o} Rosivall},
  journal={Journal of periodontal research},
  year={1993},
  volume={28 3},
  pages={191-6}
}
In the present series of investigations we first studied the local effects of exogenous substance P (SP) on the hallmarks of neurogenic inflammation, i.e. vascular permeability and blood flow, in the oral mucosa of the rat. Pretreatment with capsaicin was shown to attenuate the symptoms of neurogenic inflammation; therefore, the distribution of nerve fibers displaying substance P-like immunoreactivity (SP-IR) in the mandibular mucosa was also assessed in control rats and in animals pretreated… CONTINUE READING