Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol.

@article{Ollila2007RoleOS,
  title={Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol.},
  author={O H Samuli Ollila and Tomasz R{\'o}g and Mikko Karttunen and Ilpo Vattulainen},
  journal={Journal of structural biology},
  year={2007},
  volume={159 2},
  pages={311-23}
}
Lateral pressure profiles have been suggested to play a significant role in many cellular membrane processes by affecting, for example, the activation of membrane proteins through changes in their conformational state. This may be the case if the lateral pressure profile is altered due to changes in molecular composition surrounding the protein. In this work, we elucidate the effect of varying sterol type on the lateral pressure profile, an issue of topical interest due to lipid rafts and their… CONTINUE READING

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