Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis.

@article{Bringue2000RoleOS,
  title={Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis.},
  author={Vincent B{\'e}ringue and Marina Demoy and Corinne Ida Lasm{\'e}zas and Bruno Gouritin and Colette Weingarten and J. P. Deslys and Jean Paul Andreux and Patrick Couvreur and Dominique Dormont},
  journal={The Journal of pathology},
  year={2000},
  volume={190 4},
  pages={495-502}
}
The involvement of spleen macrophages in the early stages of scrapie pathogenesis was studied by applying the 'macrophage-suicide technique' to scrapie-infected mice. This method comprises critically the intravenous administration to mice of dichloromethylene disphosphonate encapsulated into liposomes. Depletion of spleen macrophages before scrapie infection induced an increased amount of scrapie inoculum in the spleen, consequently leading to accelerated scrapie agent replication in the early… CONTINUE READING

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