Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia.
@article{Gee2002RoleOS, title={Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia.}, author={Betty Young Gee and Stephanie C Tjen-A-Looi and J M Hill and Premjit S Chahal and John C. Longhurst}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2002}, volume={282 3}, pages={ R850-7 } }
Abdominal ischemia induces a pressor reflex caused mainly by C-fiber afferent stimulation. Because excitatory amino acids, such as glutamate, bind to N-methyl-D-aspartate (NMDA) and non-NMDA [dl-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)] receptors and serve as important spinal neurotransmitters, we hypothesized that both receptors play a role in the abdominal ischemia pressor reflex. In chloralose-anesthetized cats, NMDA receptor blockade with 25.0 mM dl-2-amino-5…
5 Citations
Glutamate's Role in a Visceral Sympathoexcitatory Reflex in Rostral Ventrolateral Medulla of Cats
- Biology
- 2006
Results suggest that glutamate in the rVLM serves as an excitatory neurotransmitter through a baroreflex-independent mechanism, and that both NMDA and AMPA receptors mediate the visceral sympathoexcitatory reflex responses.
Role of glutamate in a visceral sympathoexcitatory reflex in rostral ventrolateral medulla of cats.
- BiologyAmerican journal of physiology. Heart and circulatory physiology
- 2006
Results suggest that glutamate in the rVLM serves as an excitatory neurotransmitter through a baroreflex-independent mechanism and that both NMDA and AMPA receptors mediate the visceral sympathoexcitatory reflex responses.
Modulation of cardiovascular excitatory responses in rats by transcutaneous magnetic stimulation: role of the spinal cord.
- Biology, MedicineJournal of applied physiology
- 2006
The endogenous neurotransmitters for delta- and kappa-opioid receptors, enkephalins and dynorphin but not beta-endorphin appear to play significant roles in the spinal cord in mediating magnetic stimulation-induced modulation of cardiovascular reflex responses.
An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition
- Biology, MedicineAutonomic Neuroscience
- 2010
Acupuncture regulation of blood pressure: two decades of research.
- Medicine, BiologyInternational review of neurobiology
- 2013
References
SHOWING 1-10 OF 44 REFERENCES
Blockade of non-NMDA receptors attenuates reflex pressor response to static contraction.
- Biology, MedicineThe American journal of physiology
- 1994
The results suggest that substance P and glutamate are two neurotransmitters involved in the spinal transmission of the exercise pressor reflex and that substanceP and glutamate exert their effects via neurokinin-1 (NK-1) and non-NMDA receptors, respectively.
Spinal NMDA receptors mediate pressor responses evoked from the rostral ventrolateral medulla.
- BiologyThe American journal of physiology
- 1991
Results indicate that tonicactivation of spinal NMDA receptors participates in the maintenance of sympathetic outflow to the heart and blood vessels, pressor responses evoked from the RVM require synaptic activation of spinalNMDA receptors, and an excitatory amino acid may be the neurotransmitter of pressor pathways descending fromThe RVM to the spinal cord.
Spinal cord excitatory amino acids and cardiovascular autonomic responses.
- Biology, MedicineThe American journal of physiology
- 1994
It is concluded that intrathecal activation of NMDA and non-NMDA subtype receptors has similar but independent effects on heart rate and on blood pressure and NMDA receptors alone participate in mediation of baroreflex vasoconstrictor function, whereas both sets of receptors determine reflex sympathetic heart rate effects.
Intrathecal blockade of both NMDA and non-NMDA receptors attenuates the exercise pressor reflex in cats.
- Biology, MedicineJournal of applied physiology
- 1996
In decerebrate unanesthetized cats we tested the hypothesis that glutamatergic-receptor blockade in the lumbosacral spinal cord attenuated the reflex increases in mean arterial pressure, inspired…
Glutamate, NMDA and NMDA receptor antagonists: cardiovascular effects of intrathecal administration in the rat
- Biology, MedicineBrain Research
- 1992
NBQX, a Competitive Non-NMDA Receptor Antagonist, Reduces Degeneration due to Focal Spinal Cord Ischemia
- BiologyExperimental Neurology
- 1994
It is concluded that blockade of both NMDA and non-NMDA subtypes of glutamate receptors reduces ischemic necrosis, possibly by preventing excessive stimulation of these receptors by released excitatory amino acids in the lesion area.
Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice.
- Biology, ChemistryEuropean journal of pharmacology
- 1992
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cord
- BiologyNeuroscience
- 1993
The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats
- Biology, PsychologyNeuropharmacology
- 1984
Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder.
- Biology, MedicineThe American journal of physiology
- 1995
Data suggest that endogenous SP, acting as a sensory neurotransmitter, is involved in the excitatory cardiovascular reflex caused by chemical stimulation of the gallbladder through its action on NK1 receptors in the spinal cord.