Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.

@article{Ung2008RoleOS,
  title={Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.},
  author={Roth-V Ung and Eric S. Landry and Pascal Rouleau and Nicolas Lapointe and Claude Rouillard and Pierre A. Guertin},
  journal={The European journal of neuroscience},
  year={2008},
  volume={28 11},
  pages={2231-42}
}
A role of serotonin receptors (5-HTRs) in spinal rhythmogenesis has been proposed several years ago based mainly upon data showing that bath-applied 5-HT could elicit locomotor-like rhythms in in vitro isolated spinal cord preparations. Such a role was partially confirmed in vivo after revealing that systemically administered 5-HTR(2) agonists, such as quipazine, could induce some locomotor-like movements (LM) in completely spinal cord-transected (Tx) rodents. However, given the limited binding… CONTINUE READING

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