Role of sperm alphavbeta3 integrin in mouse fertilization.

  title={Role of sperm alphavbeta3 integrin in mouse fertilization.},
  author={C{\'e}line Chalas Boissonnas and Debbie Montjean and Corinne Lesaffre and Jana Auer and Daniel Vaiman and J P Wolf and Ahmed Ziyyat},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={239 3},
Oocyte integrins have been described as essential for fertilization. But this concept has been challenged by deletion experiments. Recently, we have shown that sperm integrin alpha6beta1 plays a determinant role in mouse gamete interaction. In this study, we demonstrate the presence of alphavbeta3 integrin by Western blot and immunofluorescence on the sperm membrane. Oocytes and/or sperm preincubations with anti-alphav or anti-beta3 antibodies were performed before in vitro fertilization on… CONTINUE READING
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