Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines.

@article{Hoffmann2005RoleOS,
  title={Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines.},
  author={Erich Hoffmann and Aleksandr S. Lipatov and Richard R. J. Webby and Elena A Govorkova and Robert James Webster},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 36},
  pages={12915-20}
}
If H5N1 influenza viruses become transmissible among humans, vaccination will offer the most effective option to limit their spread. Two human vaccine candidates recently generated by reverse genetics are based on antigenically different hemagglutinin (HA) glycoproteins derived from the A/HK/213/03 (H5N1) and A/Vietnam/1203/04 (H5N1) viruses. Their HA1 amino acid sequences differ at 10 positions, one of which (N154) introduces a potential glycosylation site in A/Vietnam/1203/04 (H5N1). To… CONTINUE READING

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