Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury.

@article{Zhang2008RoleOS,
  title={Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury.},
  author={Haiying Zhang and Sadatomo Tasaka and Yoshiki Shiraishi and Koichi Fukunaga and Wakako Yamada and Hiroyuki Seki and Yuko Ogawa and Keisuke Miyamoto and Yasushi Nakano and Naoki Hasegawa and Taku Miyasho and Ikuro Maruyama and Akitoshi Ishizaka},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 4},
  pages={356-62}
}
RATIONALE The interaction of receptor for advanced glycation end products (RAGE) and its ligands often leads to inflammatory processes or tissue injury, although the effect of the blockade of RAGE signaling on lung injury remains to be investigated. OBJECTIVES Using a murine model of lung injury induced by intratracheal lipopolysaccharide (LPS), we evaluated RAGE expression in the airspace and the effect of recombinant soluble RAGE (sRAGE) on LPS-induced lung injury. METHODS First, the… CONTINUE READING

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