Role of sodium in hemodialysis.

  title={Role of sodium in hemodialysis.},
  author={Michael J. Flanigan},
  journal={Kidney international. Supplement},
Sodium chloride is the most abundant salt in extracellular fluid. In normal individuals, the tonicity exerted by dissolved sodium chloride determines plasma osmolality and indirectly determines intracellular tonicity and cell volume. Uremic patients retain nitrogenous wastes and have an elevated plasma osmolality. While urea exhibits osmotic activity in serum, no sustained gradient can be established across cell boundaries because it readily diffuses through cell membranes. Thus, sodium remains… CONTINUE READING