Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts.

@article{Armoundas2003RoleOS,
  title={Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts.},
  author={Antonis A. Armoundas and Ion A. Hobai and Gordon F. Tomaselli and Raimond L. Winslow and Brian O'Rourke},
  journal={Circulation research},
  year={2003},
  volume={93 1},
  pages={46-53}
}
Increased Na+-Ca2+ exchange (NCX) activity in heart failure and hypertrophy may compensate for depressed sarcoplasmic reticular Ca2+ uptake, provide inotropic support through reverse-mode Ca2+ entry, and/or deplete intracellular Ca2+ stores. NCX is electrogenic and depends on Na+ and Ca2+ transmembrane gradients, making it difficult to predict its effect on the action potential (AP). Here, we examine the effect of [Na+]i on the AP in myocytes from normal and pacing-induced failing canine hearts… CONTINUE READING