Role of small conductance Ca²⁺-activated K⁺ channels in controlling CA1 pyramidal cell excitability.

@article{Chen2014RoleOS,
  title={Role of small conductance Ca²⁺-activated K⁺ channels in controlling CA1 pyramidal cell excitability.},
  author={Shmuel Chen and Felix Benninger and Yoel Yaari},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 24},
  pages={
          8219-30
        }
}
Small-conductance Ca(2+)-activated K(+) (SK or K(Ca)2) channels are widely expressed in the CNS. In several types of neurons, these channels were shown to become activated during repetitive firing, causing early spike frequency adaptation. In CA1 pyramidal cells, SK channels in dendritic spines were shown to regulate synaptic transmission. However, the presence of functional SK channels in the somata and their role in controlling the intrinsic firing of these neurons has been controversial… CONTINUE READING
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