Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin.

@article{Huo2004RoleOS,
  title={Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin.},
  author={Lihong Huo and Heike M{\"u}nzberg and Eduardo A. Nillni and Christian Bj\orbaek},
  journal={Endocrinology},
  year={2004},
  volume={145 5},
  pages={2516-23}
}
During starvation in rodents, the hypothalamic-pituitary-thyroid axis is down-regulated, resulting in low circulating thyroid hormone levels. This involves a reduction in hypothalamic TRH mRNA that is caused in part by a fall in serum leptin levels, which is sensed by neurons within the hypothalamus. The mechanism by which this regulation occurs is not… CONTINUE READING