Role of short telomeres in inducing preferential chromosomal aberrations in human ovarian surface epithelial cells: A combined telomere quantitative fluorescence in situ hybridization and whole-chromosome painting study.

@article{Deng2003RoleOS,
  title={Role of short telomeres in inducing preferential chromosomal aberrations in human ovarian surface epithelial cells: A combined telomere quantitative fluorescence in situ hybridization and whole-chromosome painting study.},
  author={Wen Deng and Sai Wah Tsao and Xin-yuan Guan and Joe N. Lucas and Annie L. M. Cheung},
  journal={Genes, chromosomes & cancer},
  year={2003},
  volume={37 1},
  pages={
          92-7
        }
}
  • Wen Deng, Sai Wah Tsao, +2 authors Annie L. M. Cheung
  • Published in Genes, chromosomes & cancer 2003
  • Biology, Medicine
  • It is well established that specific cancers and immortalized cells have nonrandom chromosome aberrations. However, little is understood about the underlying mechanism that initiates these aberrations in human cells. To examine whether human chromosomes with the shortest telomeres initiate the preferential chromosomal aberrations before cellular immortalization, we simultaneously applied telomere quantitative fluorescence in situ hybridization and specific whole-chromosome painting on… CONTINUE READING

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