Role of sex hormones in allergic inflammation in mice.

  title={Role of sex hormones in allergic inflammation in mice.},
  author={Yanira Riffo-Vasquez and Ana Paula Ligeiro de Oliveira and Clive P Page and Domenico Spina and Wothan Tavares-de-Lima},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={37 3},
BACKGROUND A number of clinical studies have documented both a pro- and anti-inflammatory role for sex hormones in the context of lung inflammation and worsening of asthma. OBJECTIVE To determine the role of sex hormones in a murine model of allergic inflammation and airway hyper-responsiveness (AHR) induced by ovalbumin (OVA). METHODS Female BALB/c were sensitized to OVA on days 0 and 7 and subsequently challenged on day 14 over a 3-day period. Mice had their ovaries removed either 7 days… CONTINUE READING


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