Role of sestrin2 in peroxide signaling in macrophages.

  title={Role of sestrin2 in peroxide signaling in macrophages.},
  author={Silke Essler and Nathalie Dehne and Bernhard Br{\"u}ne},
  journal={FEBS letters},
  volume={583 21},
Reactive oxygen species not only serve as signaling molecules, they also contribute to oxidative stress and cell damage. The thioredoxin and glutaredoxin systems form along with peroxiredoxins a precisely regulated defense system to maintain the cellular redox homeostasis. There is evidence that nitric oxide (NO) protects cells from oxidative stress by preventing inactivation of peroxiredoxins by sulfinylation. Here we demonstrate that NO and hypoxia upregulate Sestrin2 by HIF-1-dependent and… CONTINUE READING

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