Role of serum pro-hepcidin and GSTM1 and GSTT1 null polymorphisms for estimation of the risk of myocardial siderosis in children and “young adults” with β-thalassemia major

@article{Chakarov2013RoleOS,
  title={Role of serum pro-hepcidin and GSTM1 and GSTT1 null polymorphisms for estimation of the risk of myocardial siderosis in children and “young adults” with β-thalassemia major},
  author={Ivan Chakarov and Tatyana Iv Vlaykova and Emil Slavov Slavov and Rumen Marinov and Petrana Chakarova},
  journal={Comparative Clinical Pathology},
  year={2013},
  volume={23},
  pages={725-733}
}
This study aims to evaluate the serum pro-hepcidin level in β-thalassemia patients, to clarify its relation with serum level of ferritin and to assess the possible role of null polymorphisms of glutathione S-transferase genes, GSTM1 and GSTT1, for susceptibility to β-thalassemia and myocardial siderosis. The serum level of pro-hepcidin was assessed in 31 patients [16 children (52 %) and 15 young adults (48 %)] with β-thalassemia and nine healthy individuals [four children (44 %) and five young… CONTINUE READING

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