Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

@article{Gainetdinov1999RoleOS,
  title={Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.},
  author={Raul R. Gainetdinov and William C. Wetsel and Sara R Jones and Edward D. Levin and Mohamed Jaber and Marc G. Caron},
  journal={Science},
  year={1999},
  volume={283 5400},
  pages={
          397-401
        }
}
The mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice lacking the gene encoding the plasma membrane dopamine transporter (DAT) have elevated dopaminergic tone and are hyperactive. This activity was exacerbated by exposure to a novel environment. Additionally, these mice were impaired in spatial cognitive function, and they showed a decrease in locomotion in response to… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 364 CITATIONS, ESTIMATED 56% COVERAGE

Dopaminergic control of sleep-wake states.

VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS

Roundabout receptor 2 maintains inhibitory control of the adult midbrain

VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Impaired cliff avoidance reaction in dopamine transporter knockout mice

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2019

CITATION STATISTICS

  • 40 Highly Influenced Citations

  • Averaged 13 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-3 OF 3 REFERENCES

Clinical Descriptions and Diagnostic Guidelines (World Health Organization, Geneva, rev

  • The ICD-10 Classification of Mental, Behavioral Disorders
  • 10, 1992); J. M. Swanson, Curr. Opin. Psychiatry 10, 300 (1996); J. Swanson, F. X. Castellanos, M. Murias, G. LaHoste, J. Kennedy, Curr. Opin. Neurobiol. 8, 263
  • 1998
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

A Handbook for Diagnosis and Treatment (Guiford, New York, 1990); L

  • R. A. Barkley, Attention Deficit Hyperactivity Disorder
  • J. Hechtman, J. Psychiatry Neurosci. 19, 193 (1994); K. J. Gingerich, P. Turnock, J. K. Litfin, L. A. Rosen, J. Clin. Psychol. 54, 415
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Psychopharmacology: The third generation of progress

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL