Role of serotonin in cerebral oxidative stress in rats.

  title={Role of serotonin in cerebral oxidative stress in rats.},
  author={Juan R Mu{\~n}oz-Casta{\~n}eda and Pedro Montilla and Francisco Padillo and Inmaculada Bujalance and Maria Del Carmen Lara Mu{\~n}oz and Jordi Muntan{\'e} and Isaac T{\'u}nez},
  journal={Acta neurobiologiae experimentalis},
  volume={66 1},
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter synthesized by the aromatic amino acid decarboxylase using 5-hydroxytryptophan (5-HTP) as a substrate. It was recently shown that serotonin and its precursor have powerful antioxidant properties. The aim of this study was to evaluate the effect of reduction in 5-HT levels by parachlorophenylalanine (pCPA) and their restoration by 5-HTP administration on lipid peroxidation and antioxidant status in rat brain. Serotonin… CONTINUE READING
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