Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.

@article{Yamashita2001RoleOS,
  title={Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.},
  author={Hironobu Yamashita and Marja T. Nevalainen and Juliana Xu and Matthew J. LeBaron and K U Wagner and Rebecca A. Erwin and Jeffrey M. Harmon and Lothar Hennighausen and Robert A. Kirken and Hallgeir Rui},
  journal={Molecular and cellular endocrinology},
  year={2001},
  volume={183 1-2},
  pages={151-63}
}
Milk production remains suppressed in mammals during late pregnancy despite high levels of lactogenic polypeptide hormones. At parturition, associated with a precipitous fall in circulating progesterone, rising glucocorticoid levels synergize with prolactin to initiate copious milk production. This synergy is mediated at least in part through the coordinated activation of glucocorticoid receptors and transcription factor Stat5, particularly Stat5a. Here we show that two proline-juxtaposed… CONTINUE READING
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