Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.

@article{Liu2002RoleOS,
  title={Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.},
  author={Lixia Liu and Zhenheng Guo and Quyen Tieu and Anna M. Castle and David Castle},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 12},
  pages={
          4266-78
        }
}
In secretory carrier membrane proteins (SCAMPs), the most conserved structural segment is between transmembrane spans 2 and 3, facing the cytosol. A synthetic peptide, CWYRPIYKAFR (E peptide), from this segment of SCAMP2 potently inhibits exocytosis in permeabilized neuroendocrine (PC12) cells. E peptide blocked discharge of (35)S-labeled secretogranin with the same structural selectivity and potency as observed for hexosaminidase secretion in mast cells. SCAMPs 1 and 2 are concentrated… CONTINUE READING
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