Role of secreted frizzled-related protein 3 in human renal cell carcinoma.

@article{Hirata2010RoleOS,
  title={Role of secreted frizzled-related protein 3 in human renal cell carcinoma.},
  author={Hiroshi Hirata and Yuji Hinoda and Koji Ueno and Shahana Majid and Sharanjot Saini and Rajvir Dahiya},
  journal={Cancer research},
  year={2010},
  volume={70 5},
  pages={
          1896-905
        }
}
The secreted frizzled-related protein (sFRP) family plays an important role in the inhibition of the Wnt signaling pathway in various cancers. The functional significance of Wnt antagonist sFRP3 has not been investigated in renal cancer. We performed tissue microarray and found that the level of sFRP3 protein was high in normal kidney, low in primary renal cancer tissues, and high in metastatic renal cancer tissues. Therefore, we hypothesized that sFRP3 may play an important role in metastatic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

FRZB up-regulated in hepatocellular carcinoma bone metastasis.

  • International journal of clinical and experimental pathology
  • 2015
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FRZB up-regulation is correlated with hepatic metastasis and poor prognosis in colon carcinoma patients with hepatic metastasis.

  • International journal of clinical and experimental pathology
  • 2015
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Increased sFRP3 expression correlated to senescence of endothelial cells in the aging process of mice.

  • American journal of translational research
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Negative regulators of Wnt signaling pathway SFRP1 and SFRP3 expression in preterm and term pathologic placentas.

  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Angiopoietin: a TIE(d) balance in tumor angiogenesis.

  • Molecular cancer research : MCR
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2008
VIEW 1 EXCERPT