Role of science in the treatment of breast cancer when tumor multicentricity is present.


During the past 100 years, there have been two major controversies with regard to the treatment of primary breast cancer. The first controversy, which occurred approximately 35 years ago, questioned the performance of radical mastectomy, as originally proposed by Halsted in the 1890s. That controversy was resolved by the use of laboratory and clinical… (More)
DOI: 10.1093/jnci/djr240


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