Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides.

@article{Jzefowski2006RoleOS,
  title={Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides.},
  author={Szczepan J{\'o}zefowski and Timothy H. Sulahian and Mohamed Simo Arredouani and Lester Kobzik},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={80 4},
  pages={
          870-9
        }
}
The macrophage Class A scavenger receptor MARCO (macrophage receptor with a collagenous structure) functions as a pattern-recognition receptor for bacterial components, but its role in responses to CpG oligonucleotide sequences (CpG-ODN) in microbial DNA has not been characterized. Phosphorothioate (PS)-linked CpG-ODN stimulated IL-12 and NO production in wild-type but not in MARCO-deficient, thioglycollate-elicited peritoneal macrophages. MARCO and the related class A receptor SR-A belong to a… CONTINUE READING
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