Role of sarcoplasmic reticulum in the myorelaxant activity of nitric oxide donors in guinea pig gastric fundus.

@article{Petkov1998RoleOS,
  title={Role of sarcoplasmic reticulum in the myorelaxant activity of nitric oxide donors in guinea pig gastric fundus.},
  author={Georgi V. Petkov and G Spassov and Kiril K. Boev},
  journal={European journal of pharmacology},
  year={1998},
  volume={354 1},
  pages={
          59-66
        }
}
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Evidence is provided for the role of Ca 2+ release from a SR ryanodine-sensitive Ca2+ store in the maintenance of the muscle tone of the cat gastric fundus.
Role of sarcoplasmic reticulum in inhibitory junction potentials and hyperpolarizations by nitric oxide donors in opossum oesophagus
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Results support the hypothesis that subplasmalemmal Cai2+ elevation, via vectorial Ca2+ release from superficial SR toward the plas malemma, may be an important mechanism by which NO, from NO‐liberating compounds or released from inhibitory neurones induces relaxation and i.j.p.ps in opossum oesophagus.
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The authors' data suggest that, in gastric fundus smooth muscles, NO-liberating substances and cGMP analogues contribute to the activation of a Ca2+ -release mechanism from the cell bulk, i.e. the myoplasm surrounding the contractile filaments, towards the plasma membrane, crossing the SR Ca2-stores.
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Results indicate that the proper functioning of SR Ca+(+)-pump ATPase is necessary for elicitation of relaxation by NTG and ANF and Enhanced sequestration of Ca++ by SR may be an important mechanism by which these compounds induce relaxation in this type of smooth muscle.
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TLDR
The mechanism of action of vasoactive intestinal peptide was examined in isolated gastric and taenia coli muscle cells and compared with that of nitric oxide, sodium nitroprusside, and isoproterenol to conclude that cAK and cGK can be activated separately and mediate relaxation independently.
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