Role of repeated lung injury and genetic background in bleomycin-induced fibrosis.

@article{Chung2003RoleOR,
  title={Role of repeated lung injury and genetic background in bleomycin-induced fibrosis.},
  author={Man Pyo Chung and Martha M. Monick and Nabeel Y Hamzeh and Noah S Butler and Linda S. Powers and Gary W. Hunninghake},
  journal={American journal of respiratory cell and molecular biology},
  year={2003},
  volume={29 3 Pt 1},
  pages={375-80}
}
Current hypotheses of the pathogenesis of many forms of pulmonary fibrosis suggest that (i) a stimulus results in repeated or prolonged episodes of lung injury, and (ii) genetic factors modulate the outcome of the injury. The commonly employed single-exposure bleomycin model results in only temporary fibrosis. Therefore, we evaluated whether repeated bleomycin exposures, in the setting of a genetic background more likely to develop a T helper 2 (Th2) response, would induce prolonged fibrosis… CONTINUE READING
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