Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition.

@article{Haas1993RoleOR,
  title={Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition.},
  author={John A Haas and Ali A Khraibi and Mark A. Perrella and Franklyn G. Knox},
  journal={The American journal of physiology},
  year={1993},
  volume={264 3 Pt 2},
  pages={F411-4}
}
Systemic inhibition of nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA) increases renal perfusion pressure (RPP) and urinary sodium excretion. Increased RPP has been proposed as one of the mechanisms for the natriuresis caused by intravenous infusion of L-NMMA. We tested the hypothesis that increases in renal interstitial hydrostatic pressure (RIHP) are required for the natriuresis of L-NMMA infusion. Experiments were performed in four groups of Sprague-Dawley rats in which partial… CONTINUE READING

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