Role of regulatory T cells for the treatment of type 1 diabetes mellitus.

  title={Role of regulatory T cells for the treatment of type 1 diabetes mellitus.},
  author={Elmar Jaeckel and Nonsikelelo Mpofu and Nadja Saal and Michael P. Manns},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={40 2},
Beta-cell specific autoreactive T cells can be found in patients with type I diabetes (T1D) and in healthy controls. They are usually controlled by a network of regulatory mechanisms including CD4+CD25+Foxp3+ regulatory T cells (Tregs). It was suspected that defects in Treg number and activity are causally related to the development of T1D. Although there are hints that this concept might be true, it is neither proven in animal models nor in patients with T1D. However, increasing the number of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 15 extracted citations


Publications referenced by this paper.
Showing 1-10 of 116 references

Func - tional waning of naturally occurring CD 4 + regulatory T - cells contributes to the onset of autoimmune

  • S Gregori, N Giarratana, S Smiroldo, L Adorini
  • 2008

T Tregs Cells for Type 1 DM .

  • E Jaeckel
  • Horm Metab Res
  • 2008

Dendritic cells with TGF - beta 1 differentiate naive CD 4 + CD 25 - T cells into islet - protective Foxp 3 + regulatory T cells

  • D Mucida, Y Park, G Kim, O Turovskaya, I Scott, M Kronenberg
  • Proc Natl Acad Sci USA
  • 2007

Similar Papers

Loading similar papers…