Role of reactive oxygen species in transforming growth factor-beta1-induced extracellular matrix accumulation in renal tubular epithelial cells.

@article{Rhyu2012RoleOR,
  title={Role of reactive oxygen species in transforming growth factor-beta1-induced extracellular matrix accumulation in renal tubular epithelial cells.},
  author={D Y Rhyu and Jehyun Park and Bishwa Ram Sharma and Hunjoo Ha},
  journal={Transplantation proceedings},
  year={2012},
  volume={44 3},
  pages={625-8}
}
Tubulointerstitial fibrosis, which is characterized by the progressive accumulation of extracellular matrix (ECM), is the main feature of chronic renal allograft dysfunction. Transforming growth factor-β1 (TGF-β1) is the key inducer of tubulointerstitial fibrosis. Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of ECM degradation, is increasingly recognized to play an important role in renal fibrosis. ECM accumulation is the net result of ECM synthesis and degradation. We… CONTINUE READING

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