Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia.

@article{Niecknig2012RoleOR,
  title={Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia.},
  author={Helene Niecknig and Suzan Tug and Buena Delos Reyes and Michael Kirsch and Joachim Fandrey and Utta Berchner-Pfannschmidt},
  journal={Free radical research},
  year={2012},
  volume={46 6},
  pages={705-17}
}
The function and survival of eukaryotic cells depends on a constant and sufficient oxygen supply. Cells recognize and respond to hypoxia by accumulation of the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of an oxygen-sensitive HIF-1α and a constitutive HIF-1β subunit. Besides physiology, HIF-1 induction is involved in major pathological processes such as cardiovascular disease, inflammation and cancer, which are associated with the formation of reactive oxygen species (ROS… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

  • K Lisy, DJ Peet
  • Genes Dev
  • 2001
Highly Influential
3 Excerpts

hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

  • N Masson, C Willam, PH Maxwell, CW Pugh, PJ. Ratcliffe
  • J Biol Chem
  • 1996
Highly Influential
4 Excerpts

The role of redox changes in oxygen [ 35 ] sensing

  • P Chomczynski, N Sacchi
  • Respir Physiol Neurobiol
  • 2010

Calpain [ 16 ] mediates a von Hippel – Lindau proteinindependent destruction of hypoxiainducible factor - 1 alpha

  • J Zhou, R Kohl, B Herr, R Frank, B Brune
  • Cell Cycle
  • 2009

The peptidyl prolyl cis / trans isomerase FKBP 38 determines hypoxiainducible transcription factor prolyl4hydroxylase PHD 2 protein stability

  • S Barth, J Nesper, PA Hasgall, R Wirthner, KJ Nytko
  • J Biol Chem
  • 2009

Similar Papers

Loading similar papers…