Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility.

@article{Venkatesh2009RoleOR,
  title={Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility.},
  author={Sundararajan Venkatesh and Munusamy Deecaraman and Rajeev Kumar and Monis Bilal Shamsi and Rima Dada},
  journal={The Indian journal of medical research},
  year={2009},
  volume={129 2},
  pages={127-37}
}
Infertility affects about 15 per cent married couples half of which may be attributed to men with low sperm motility (asthenozoospermia), low sperm count (oligozoospermia) or abnormal sperm morphology (teratozoospermia). As mitochondria are the energy source for initiation, differentiation and function of the germ cells, mutation in mitochondrial genome can impair the formation of mature spermatozoa. Mutations in mitochondrial genome are identified in patients with fertility problems. However… CONTINUE READING

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Oxidative stress and sperm mitochondrial DNA mutation in idiopathic oligoasthenozoospermic (OA) infertile men

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