Role of reactive oxygen species in neonatal pulmonary vascular disease.

  title={Role of reactive oxygen species in neonatal pulmonary vascular disease.},
  author={Stephen Wedgwood and Robin Heise Steinhorn},
  journal={Antioxidants & redox signaling},
  volume={21 13},
SIGNIFICANCE Abnormal lung development in the perinatal period can result in severe neonatal complications, including persistent pulmonary hypertension (PH) of the newborn and bronchopulmonary dysplasia. Reactive oxygen species (ROS) play a substantive role in the development of PH associated with these diseases. ROS impair the normal pulmonary artery (PA) relaxation in response to vasodilators, and ROS are also implicated in pulmonary arterial remodeling, both of which can increase the… CONTINUE READING
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