Role of reactive oxygen species in intestinal diseases.

@article{vanderVliet1992RoleOR,
  title={Role of reactive oxygen species in intestinal diseases.},
  author={Albert van der Vliet and Aalt Bast},
  journal={Free radical biology \& medicine},
  year={1992},
  volume={12 6},
  pages={
          499-513
        }
}

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The available data suggest that oxygen radicals appear to be a fundamental mechanism of tissue injury in the pathogenesis of various disorders of the digestive system.

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The results indicate that oxygen radicals generated by xanthine oxidase are very important, but not the only significant factor in the small intestinal reperfusion damage.

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It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.

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It is indicated that oxygen-derived free radicals, generated by the reaction of hypoxanthine with xanthine oxidase, increase intestinal vascular permeability to an extent comparable with that observed in preparations subjected to 1 h of ischemia.
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