Role of reactive oxygen species in intestinal diseases.

  title={Role of reactive oxygen species in intestinal diseases.},
  author={Albert van der Vliet and Aalt Bast},
  journal={Free radical biology \& medicine},
  volume={12 6},

Inflammatory bowel disease, free radicals and zinc

  • H. F. Goode
  • Biology
    Journal of gastroenterology and hepatology
  • 1994
This study suggests that although free radicals have been strongly implicated in IBD, and the protective antioxidant zincdependent enzymes SOD and MT are both zinc-dependent enzymes which play important roles in the scavenging of free radicals, SOD activity has not been found to correlate particularly well with zinc state.

Raxofelast (IRFI 016): A New Hydrophilic Vitamin E‐Like Antioxidant Agent

Normally, a number of defense mechanisms limit the levels of potentially dangerous reactive oxygen species, and vitamin E, which is considered to be the first line of defense against lipid peroxidation, protects polyunsaturated lipids in biomembranes.

Enhanced Oxidative Stress and Leucocyte Activation in Neoplastic Tissues of the Colon

Levels of lipid peroxides and of thiobarbituric acid reactive substances were significantly increased and leukocyte activation was also higher in the carcinogenic tissue, indicating a possible contribution of these cells to a further oxidative stress-derived tissue injury in the neoplastic tissue and its surroundings.

Effects of meloxicam on oxygen radical generation in rat gastric mucosa

The hypothesis that in addition to suppresion of prostaglandin synthesis, oxygen free radicals, probably derived via the action of xanthine oxidase, the decrease in superoxide dismutase activity, and the depletion of mucosal glutathione contribute to the pathogenesis of meloxicam-induced ulceration is supported.

Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery

It is suggested that butyrate rescues the redox machinery and controls the intracellular ROS balance thus switching off EC-LPS induced inflammatory response in intestinal epithelial cells and in CrD colonic mucosa.

Inhibition of p38 MAPK improves intestinal disturbances and oxidative stress induced in a rabbit endotoxemia model

The aims of this study were to investigate the role of p38 MAPK in the effect of LPS on the acetylcholine, prostaglandin E2 and KCl‐induced contractions of rabbit duodenum and the oxidative stress status, and to localize the active form of p 38 in the intestine.



Role of oxygen-derived free radicals in digestive tract diseases.

The available data suggest that oxygen radicals appear to be a fundamental mechanism of tissue injury in the pathogenesis of various disorders of the digestive system.

Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage.

The results indicate that oxygen radicals generated by xanthine oxidase are very important, but not the only significant factor in the small intestinal reperfusion damage.

Oxygen-derived free radicals in postischemic tissue injury.

  • J. McCord
  • Biology, Medicine
    The New England journal of medicine
  • 1985
It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.

Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals.

Findings support the hypothesis that xanthine oxidase is the source of oxygen radicals produced during ischemia and indicate that hydroxyl radicals, derived from the superoxide anion, are primarily responsible for the vascular injury associated with intestinal ischemIA.

Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis.

Superoxide dismutase/catalase markedly improved the PAF-induced lesions, indicating that most of the intestinal damage after PAF injection is because of the release of oxygen radicals.

Oxygen radicals in intestinal ischemia and reperfusion.

A role for iron in oxidant-mediated ischemic injury to intestinal microvasculature.

The hypothesis that iron plays an important role in the formation of hydroxyl radicals after reperfusion of the ischemic bowel is supported.

Oxygen radicals: effects on intestinal vascular permeability.

It is indicated that oxygen-derived free radicals, generated by the reaction of hypoxanthine with xanthine oxidase, increase intestinal vascular permeability to an extent comparable with that observed in preparations subjected to 1 h of ischemia.