Role of reactive oxygen species in cupric 8-quinolinoxide-induced genotoxic effect.

@article{You2001RoleOR,
  title={Role of reactive oxygen species in cupric 8-quinolinoxide-induced genotoxic effect.},
  author={Byoung-moon You and Ying Wang and Mu-Yi Kuo},
  journal={Mutation research},
  year={2001},
  volume={491 1-2},
  pages={
          45-56
        }
}
  • Byoung-moon You, Ying Wang, Mu-Yi Kuo
  • Published 2001
  • Biology, Medicine
  • Mutation research
  • This study demonstrates that cupric 8-quinolinoxide (CuQ) has induced genetic toxicity in bacteria and mammalian cells through a mechanism of reactive oxygen species (ROS) generation. In the Ames test with rat liver S9, CuQ dose-dependently caused a point mutation in Salmonella typhimurium TA100. The effect of CuQ on DNA damage in HL60 and V79 cells identified in the comet assay is direct and enhanced by the addition of S9. Meanwhile, the tailing length of comet DNA is related to the increasing… CONTINUE READING