Role of reactive oxygen in phospholipase A2 activation by ischemia/reperfusion of the rat kidney

@article{Goto1999RoleOR,
  title={Role of reactive oxygen in phospholipase A2 activation by ischemia/reperfusion of the rat kidney},
  author={Shinichi Goto and Harumasa Nakamura and Hiroaki Morooka and Yoshiaki Terao and Osamu Shibata and Koji Sumikawa},
  journal={Journal of Anesthesia},
  year={1999},
  volume={13},
  pages={90-93}
}
Purpose. To investigate the role of phospholipase A2 (PLA2) in reperfusion injury of the kidney in an in vivo animal model, renal mitochondrial PLA2 activity was measured under three different conditions. Methods. Male Wistar rats (n = 72) anesthetized with pentobarbital underwent renal ischemia surgically for 45 min and were reperfused for the indicated time (renal ischemia/reperfusion). Treatments included reperfusion for various predetermined periods (phase 1), exposure to hyperbaric oxygen… CONTINUE READING
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