Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione.

@article{Lash2007RoleOR,
  title={Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione.},
  author={Lawrence H Lash and David Alan Putt and Feng Xu and Larry H. Matherly},
  journal={Chemico-biological interactions},
  year={2007},
  volume={170 2},
  pages={124-34}
}
The tripeptide GSH is important in maintenance of renal redox status and defense against reactive electrophiles and oxidants. Previous studies showed that GSH is transported across the basolateral plasma membrane (BLM) into the renal proximal tubule by both sodium-coupled and sodium-independent pathways. Substrate specificity and inhibitor studies suggested the function of several carriers, including organic anion transporter 3 (Oat3). To test the hypothesis that rat Oat3 can function in renal… CONTINUE READING

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