Role of quinones in toxicology.

@article{Bolton2000RoleOQ,
  title={Role of quinones in toxicology.},
  author={Judy L Bolton and Michael A. Trush and Trevor M Penning and Glenn Dryhurst and Terrence J. Monks},
  journal={Chemical research in toxicology},
  year={2000},
  volume={13 3},
  pages={
          135-60
        }
}
Quinones represent a class of toxicological intermediates which can create a variety of hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis. The mechanisms by which quinones cause these effects can be quite complex. Quinones are Michael acceptors, and cellular damage can occur through alkylation of crucial cellular proteins and/or DNA. Alternatively, quinones are highly redox active molecules which can redox cycle with their semiquinone radicals, leading… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 415 CITATIONS, ESTIMATED Infinity% COVERAGE

415 Citations

02040'93'98'04'10'16
Citations per Year
Semantic Scholar estimates that this publication has 415 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…