Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia.

@article{Husmann1997RoleOP,
  title={Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia.},
  author={Linda K Husmann and Daniel L Yung and Susan K. Hollingshead and June R. Scott},
  journal={Infection and immunity},
  year={1997},
  volume={65 4},
  pages={1422-30}
}
To investigate the role of putative virulence factors of Streptococcus pyogenes (group A streptococcus; GAS) in causing disease, we introduced specific mutations in GAS strain B514, a natural mouse pathogen, and tested the mutant strains in two models of infection. To study late stages of disease, we used our previously described mouse model (C3HeB/FeJ mice) in which pneumonia and systemic spread of the streptococcus follow intratracheal inoculation. To study the early stages of disease, we… CONTINUE READING
45 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…