Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion.

@article{Lakshminrusimha2013RoleOP,
  title={Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion.},
  author={Satyanarayana Lakshminrusimha and Madathilparambil V. Suresh and Paul Knight and Sylvia F. Gugino and Bruce A Davidson and Jadwiga D. Helinski and Lori C. Nielsen and James A Russell and Bi Yu and Lixia Zeng and Subramaniam Pennathur and Krishnan Raghavendran},
  journal={Shock},
  year={2013},
  volume={39 3},
  pages={
          278-85
        }
}
The mechanisms contributing to hypoxia in lung contusion (LC) remain unclear and not temporally associated with the peak onset of acute inflammation. We investigated the role of oxidative stress in alteration of pulmonary arterial (PA) reactivity following LC. In addition, the role of antioxidants in reversing this process was examined. PaO2 and PA reactivity were measured in rats subjected to bilateral LC. Rings were pretreated with a nitric oxide synthase (NOS) inhibitor, L-nitro arginine (10… CONTINUE READING
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