Role of pulmonary alveolar macrophages in defense of the lung against Pseudomonas aeruginosa.

@article{Cheung2000RoleOP,
  title={Role of pulmonary alveolar macrophages in defense of the lung against Pseudomonas aeruginosa.},
  author={Dorothy On Yan Cheung and Keith Halsey and David Paul Speert},
  journal={Infection and immunity},
  year={2000},
  volume={68 8},
  pages={
          4585-92
        }
}
Alveolar macrophages (AM) provide one of the first lines of defense against microbial invasion in the lower airways. The role of AM in the clearance of Pseudomonas aeruginosa in mice after intrapulmonary challenge was evaluated. AM were depleted by intranasal administration of liposome-encapsulated dichloromethylene diphosphonate. At 24 h following the instillation of liposomes, a sublethal dose of P. aeruginosa was inoculated intranasally. Spleen, liver, and lung tissue was then evaluated for… CONTINUE READING

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