Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats.

@article{Pan1999RoleOP,
  title={Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats.},
  author={H L Pan and J C Longhurst and James C Eisenach and Shao Rui Chen},
  journal={The Journal of physiology},
  year={1999},
  volume={518 ( Pt 3)},
  pages={857-66}
}
1. Chest pain caused by myocardial ischaemia is mediated by cardiac sympathetic afferents. The mechanisms of activation of cardiac afferents during ischaemia remain poorly understood. Increased lactic acid production is associated closely with myocardial ischaemia. The present study examined the role of protons generated during ischaemia in activation of cardiac sympathetic C-fibre afferents. 2. Single-unit activity of cardiac afferents innervating both ventricles was recorded from the left… CONTINUE READING