Role of proteolysis in development of murine adipose tissue.

@article{Christiaens2008RoleOP,
  title={Role of proteolysis in development of murine adipose tissue.},
  author={Valerie Christiaens and Ilse Scroyen and Henri roger Lijnen},
  journal={Thrombosis and haemostasis},
  year={2008},
  volume={99 2},
  pages={
          290-4
        }
}
Obesity is a common disorder, and related diseases such as diabetes, atherosclerosis, hypertension, cardiovascular disease and cancer are a major cause of mortality and morbidity in Western-type societies. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems cooperate in these processes. A nutritionally… 
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Citation Type

Murine models of obesity and hormonal therapy.
  • H. Lijnen
  • Biology, Medicine
    Thrombosis research
  • 2011
Obesity and vascular risk.
  • H. Lijnen
  • Biology, Medicine
    Hamostaseologie
  • 2009
TLDR
Venous or arterial thrombosis models in obese mice confirm a prothrombotic risk associated with obesity and a role of the fibrinolytic and matrix metalloproteinase systems in these processes.
Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects
Abstract Matrix metalloproteinases (MMPs) play an important role during physiological tissue remodeling in embryonic development and angiogenesis, as well as in pathophysiological conditions such as…
Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity.
Adipocyte extracellular matrix composition, dynamics and role in obesity
TLDR
In the obese, overgrowth of adipocytes may lead to instability of the ECM, possibly mediated by hypoxia.
Altered Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Matured Rat Adipocytes in Vitro
TLDR
In obese adipocytes cultured under conditions of high or low glucose and with or without insulin supplementation, there was altered expression of adipokines, similar to the change in adipose tissue in obese subjects, and the expression of MMP3 and TIMP3 was inhibited.
Macrophage elastase (MMP-12) in expanding murine adipose tissue.
Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels
TLDR
It is proposed that the alteration in MMP15, VEGF-B, V EGF-C and VegF-D gene expression may be caused by one of the relevant adipose tissue processes related to the development of IR, and the up-regulation of VEGf-A in adipose tissues could have a relationship with the prevention of this pathology.
Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes
TLDR
It is suggested that MMP-13 may play a major role in adipose development and its inhibition could be a potential strategy to prevent obesity.
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing
TLDR
Evidence that adiposity may exacerbate age-related sarcopenia is provided and some emerging concepts of adipose-skeletal muscle communication including the secretion and processing of novel myokine and adipokines and the role of extracellular vesicles in mediating inter-tissue cross talk via lncRNAs and miRNAs are outlined in the context of sarc Openia, ageing, and obesity.
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